PRE-CLINICAL APPLICATIONS
Current imaging modalities limit the ability of preclinical researchers to do high throughput monitoring of tumor growth and response to drugs in vivo.
Current whole-body optical imaging technologies that offer high throughput are difficult to adapt to small animals due to four challenges:
The need to genetically modify cells to make them visible, potentially altering the way that they respond to drugs
High tissue autofluorescence (impacting signal/ background ratio)
Emitted light has poor tissue penetration thus limiting imaging depth and resolution
Little or no ability to visualize liquid tumors
SOLID TUMOR IMAGING
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METASTATIC TUMOR STUDIES
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LIQUID TUMOR IMAGING
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MOLECULAR PHENOTYPING
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PDX STUDIES
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